The African clawed frog had started the spread of the Chytrid fungus. The fungus was devastating to the world's amphibians. It is threatening many frogs worldwide. The fungus is responsible for destroying many species in Central America and North America. The fungus causes a thickening of skin, which prevents breathing and electrolyte balance. It can lead to cardiac arrest. But luckily, some frogs are starting to grow a natural defense system against the fungus. This fungus has caused catastrophic die-offs in little time.